Special Issue on Immunotherapy and Brain Tumors

Submission Deadline: Mar. 25, 2020

Please click the link to know more about Manuscript Preparation: http://www.ijneurosurgery.org/submission

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Special Issue Flyer (PDF)
  • Lead Guest Editor
    • Cynthia Kassab
      The University of Texas MD Anderson Cancer Center,  Houston, USA
  • Guest Editor
    Guest Editors play a significant role in a special issue. They maintain the quality of published research and enhance the special issue’s impact. If you would like to be a Guest Editor or recommend a colleague as a Guest Editor of this special issue, please Click here to complete the Guest Editor application.
    • Eric Holland
      Fred Hutchinson Cancer Research Center and UW Medicine, Washington, USA
    • Sanaalarab Al Enazy
      The University of Texas MD Anderson Cancer Center, Houston, USA
    • Dolores Hambardzumyan
      Emory University School of Medicine, Atlanta, USA
    • Hussein Tawbi
      The University of Texas MD Anderson Cancer Center,  Houston, USA
    • Pravesh Gupta
      The University of Texas MD Anderson Cancer Center,  Houston, USA
    • Lynette Phillips
      The University of Texas MD Anderson Cancer Center,  Houston, USA
    • Marc Daou
      Department of Neurosurgery, MD Anderson Cancer Center, Houston, USA
  • Introduction

    “William Bradley Coley, surgeon, medical discoverer, and director of medical research; who learned to cure by surgery ills that foiled its art. And without surgery, others beyond its reach.”-Harvard University 1911 upon receiving his degree of Honorary Master of Arts.
    This special issue focuses on understanding brain tumors. It includes topics regarding benign and malignant brain tumors, with an emphasis on brain metastases as the most common brain tumors overall, and on gliomas as the most common primary tumors of the central nervous system. It covers epidemiology data, translational research and clinical implications, from bench to bedside. This issue discusses fundamental scientific mechanisms behind the development and evolution of brain tumors such as driver mutations, epigenetics and potential risk factors. Clinical impression of brain tumors are also discussed and correlated to tumor location and subtype with a focus on the new WHO molecular classification of gliomas. For so long, the central nervous system was believed, like the eye, to be “immunologically privileged”, which means its immune system has its own defenses and does not rely on the systemic immunity to fight a disease. In fact, this phenomenon emanated from our anatomo-histological ignorance of that territory. Currently, our understanding of the brain opened the door to the application of systemic therapies and has proven to be successful, for example the discovery of immune checkpoint inhibitors for the treatment of malignant melanoma with brain metastases. What are the mechanisms behind this success? Did it succeed in different types of brain cancer? And why?
    This issue addresses these questions and provides information on current practices in the treatment of brain tumors, more specifically immunotherapy outcomes and updates on successful and ongoing clinical trials.

    Aims and Scope:

    1. Primary brain tumors
    2. Brain metastasis
    3. Brain blood barrier
    4. Immunotherapy
    5. Glioma/Glioblastoma
    6. Current treatment for brain tumors
    7. Brain tumors genomic analysis
    8. CAR-T therapy
    9. Tumor microenvironment
    10. Nanoparticles
    11. Translational research
    12. Clinical trials
    13. Immune Checkpoints

  • Guidelines for Submission

    Manuscripts can be submitted until the expiry of the deadline. Submissions must be previously unpublished and may not be under consideration elsewhere.

    Papers should be formatted according to the guidelines for authors (see: http://www.ijneurosurgery.org/submission). By submitting your manuscripts to the special issue, you are acknowledging that you accept the rules established for publication of manuscripts, including agreement to pay the Article Processing Charges for the manuscripts. Manuscripts should be submitted electronically through the online manuscript submission system at http://www.sciencepublishinggroup.com/login. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal and will be listed together on the special issue website.